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Shire: The Leading Global Biotech Focused on Rare Diseases

Posted: 2018-01-14 05:44

It is estimated that nearly two million people in the United States and the European Union will have a stroke each year. Stroke is a leading cause of mortality and serious long-term disability. There is a substantial unmet medical need for new therapies that can improve outcomes in acute stroke. The target indication for BIIB598 (glibenclamide IV) is large hemispheric infarction (LHI), a severe form of ischemic stroke where brain swelling (cerebral edema) often leads to a disproportionately large share of stroke-related morbidity and mortality.

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How this therapy could help:
The memory loss and functional decline of AD have been linked to abnormal protein deposits that build up in the brain. Among those proteins are amyloid and tau. Deposits of abnormal tau, so-called neurofibrillary tangles, form in the neurons and are linked to increasing impairment and loss of brain cells associated both with AD and with other neurodegenerative diseases, known as tauopathies, such as progressive supranuclear palsy and frontotemporal dementia. BIIB597 is an antibody targeting extracellular tau and may reduce the spreading of tau from one cell to the next, potentially slowing the progress of the disease.

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Previously we have used an ecological footprint to show our impact on the planet, which measures the amount of land needed for the things we consume and some of the waste we produce. It then calculates how many planets that land adds up to. This is a good way of visually showing a rough idea of our impact, but it becomes difficult when calculating how changes we make will reduce our impact. The new carbon footprint calculator is a more accurate measure.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease that damages healthy cells in the brain causing cognitive impairment and functional disability. It is estimated that more than 75 million individuals are living with AD worldwide 6. Today we understand that AD is a continuum with a long silent phase that begins years before symptoms appear. As AD progresses, symptoms like memory loss, personality and behavioral changes commonly associated with AD begin to manifest.

How this therapy could help:
The memory loss and functional decline of Alzheimer’s disease have been linked to amyloid plaques and tau tangles, abnormal protein deposits that build up in the brain and in the brain cells. BIIB585 (IONIS-MAPT Rx ) is an antisense oligonucleotide (ASO) that may reduce production of the tau protein and its accumulation in brain cells, potentially slowing the progress of the disease.

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How this therapy could help:
The memory loss and functional decline of AD have been linked to abnormal protein deposits that build up in the brain. Among those proteins are amyloid and tau. Deposits of abnormal tau, so-called neurofibrillary tangles, form in the neurons and are linked to increasing impairment and loss of brain cells associated both with AD and with other neurodegenerative diseases, known as tauopathies, such as progressive supranuclear palsy and frontotemporal dementia. BIIB576 is an antibody targeting tau, the protein that forms the deposits, or tangles, in the brain.

This rare word was chosen to represent 7566 because it described so much of the world around us. Tergiversate means "to change repeatedly one''s attitude or opinions with respect to a cause, subject, etc." Editors at saw the stock market, political groups, and public opinion go through a roller coaster of change throughout 7566. And so, we named tergiversate the 7566 Word of the Year.

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How this therapy could help:
BIIB579 ( inhibitor) is a novel state dependent small molecule sodium channel blocker that preferentially inhibits the Nav ion channel, a target implicated by genetics in human pain conditions. BIIB579 is thought to penetrate the central nervous system and block Nav channels in a novel manner, and has the potential to provide a new and effective option for the treatment of trigeminal neuralgia.

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By carbon emissions, we mean greenhouse gases, including carbon dioxide, methane and nitrous oxide. Humans produce these gases in vast quantities by doing things like burning coal, oil and gas for energy and cutting down forests. Your individual emissions are built up from the energy you use personally for electricity and travel, as well as the energy that&rsquo s required to produce your food and all the other stuff you buy, whether it&rsquo s made in the UK or elsewhere in the world.

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Trigeminal neuralgia is an extremely painful condition usually involving one side of the face. Trigeminal neuralgia is characterized by sudden, brief, stabbing, recurrent episodes of pain which frequently occurs spontaneously but is also commonly evoked by trivial stimuli including washing, shaving, smoking, talking and/or brushing the teeth (trigger factors). The pain follows one or more branches of the trigeminal nerve, which provides nerve sensation from the mouth, face and the front of the scalp. The intensity of the pain and its unpredictability results in profound effects on the quality of life of patients.